4th Century
St. Cyril of Jerusalem
Patristic Period
St. Cyril of Jerusalem (c. 313 – 386), Bishop of Jerusalem and Doctor of the Church. Wikipedia
"Having learned these things, and been fully assured that the seeming bread is not bread, though sensible to taste, but the Body of Christ; and that the seeming wine is not wine, though the taste will have it so, but the Blood of Christ... "
Catechetical Lecture 22
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Why this quote matters
Catechetical instruction on reality beyond appearances.
Source citation: Mystagogical Catechesis 4.